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Hyaluronic Acid: The Underappreciated Miracle Nutrient


The above picture, A, exhibits collagen deposition (fluorescent inexperienced) in tendon tissue after stimulation by hyaluronic acid. Picture B exhibits nearly no collagen when hyaluronic acid shouldn’t be added. (From Oliva 2021 through Inventive Commons License.)

Many individuals are aware of hyaluronic acid (HA) as a topical agent, utilized by many girls to enhance pores and skin hydration and clean wrinkles, given HA’s capacity to bind appreciable portions of water molecules. HA can also be injected into joints to extend joint lubrication (knees, hips, shoulders), into pores and skin as a short lived filler to cut back wrinkles, administered into the colon through enema to cut back the irritation of ulcerative colitis, and utilized topically within the vagina as a lubricant. However the true energy of hyaluronic acid comes with oral ingestion, simply because it was presupposed to happen if we added again misplaced dietary sources.

Organ meats, particularly mind, kidney, coronary heart, intestines, and pores and skin, are wealthy in HA. The fashionable aversion to organ meats has due to this fact precipitated a widespread lack of HA consumption that, I imagine, is inflicting accelerated growing older of pores and skin, joints, and different organs, maybe together with the mind. Lack of HA compromises the intestinal barrier to microbial byproducts and permits larger intestinal and body-wide irritation.

HA content material of organs drops as we age. Age-related discount is particularly marked in pores and skin, with older individuals having as much as 90% much less dermal HA in comparison with younger individuals. HA is ample in joints, discovered each in cartilage and within the joint lubricant, additionally lowered in amount as we age. HA can also be present in beneficiant portions in human breast milk, essential for gastrointestinal maturation of the breastfeeding toddler (and one more deficiency of artificial toddler formulation).

It’s clear that orally-ingested HA makes its approach to the dermal layer of pores and skin, the joint lubricating fluid in knees, hips and different joints, tendons and ligaments, the eyes, and different organs. After ingestion, HA is metabolized by intestine microbes into smaller fragments which can be absorbed and distributed all through the physique. Because the picture above demonstrates, HA stimulates collagen deposition (as does collagen supplementation, additionally).

HA additionally has prebiotic properties and has been proven to markedly enhance the inhabitants of Akkermansia muciniphila, the keystone species that exerts quite a few helpful metabolic results together with lowered insulin resistance, lowered blood sugar, and elevated manufacturing of intestinal mucus. One other keystone species, Faecalibacterium prausnitzii, produces elevated portions of helpful fatty acids akin to butyrate when “fed” HA. Utilized orally, HA additionally reduces oral pathogens.

HA ingestion due to this fact may be anticipated to:

    • Enhance pores and skin moisture and scale back wrinkle depth
    • Enhance joint lubrication (glycosaminoglycan and proteoglycans) and scale back arthritis ache

By the way in which, if the proof demonstrating that HA, particularly when mixed with collagen hydrolysates additionally absent from the fashionable food regimen, reduces arthritis ache, will increase joint lubrication, and may enhance cartilage quantity, why are docs so eager on injecting HA immediately into joints, however not on oral supplementation? Ah, nicely, you’ll be able to cost cash for injections, however not for advocating an oral complement.

  • Yield metabolic well being enhancements—no less than partly as a result of prebiotic fiber properties of HA
  • Scale back intestinal irritation by rising the intestinal immune response
  • Scale back penetrability of the gastrointestinal lining (thereby probably decreasing endotoxemia and body-wide irritation)
  • Improved wound therapeutic

According to the consumption of one thing that ought to be a pure part of food regimen, no adversarial results of HA have ever been reported throughout dozens of human medical trials.

You’ll be able to certainly get hold of HA by bringing organ meats again into your food regimen. Most trendy individuals, nevertheless, discover this objectionable. On the very least, you possibly can enhance HA consumption by consuming the pores and skin on poultry (NEVER boneless, skinless rooster breast, the epitome of low-fat blunders!) and fish, devour sausages encased in pure casings, make soups from the carcass of animals you’ve consumed, however the whole amount ingested will probably be modest. Supplementation can due to this fact be the answer.

If we had been to devour the mind of an animal, we’d get hold of round 7.4 grams of HA from a 4-ounce serving. A variety of HA doses have been explored however sometimes 40-240 mg per day. However is that the best consumption? That is an unanswered query, however can be price exploring. As a result of HA is so water-absorbent, small portions generate substantial hydrating results.

Picture supply: Oliva F, Marsilio E, Asparago G, Frizziero A, Berardi AC, Maffulli N. The Affect of Hyaluronic Acid on Tendon Physiology and Its Scientific Utility in Tendinopathies. Cells. 2021 Nov 9;10(11):3081.

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