INTEGRA’s VIAFLO 384 proves indispensable in neurodegeneration analysis

Scientists at Rejuveron Vascular Therapeutics AG, an organization specializing within the growth of therapies to sort out neurodegeneration, are utilizing INTEGRA’s VIAFLO 384 handheld digital pipette to speed up their analysis. Combining this handy benchtop system with endothelial cells cultured in Corning® HTS Transwell® 96 effectively plates permits the workforce to analyze the flexibility of medication to penetrate the blood mind barrier (BBB).

Picture Credit score: INTEGRA

Vasco Ledebur de Antas de Campos, Head of Discovery Biology at Rejuveron Vascular Therapeutics, defined: “We deposit cells within the Transwells, and incubate them to type a monolayer on the filter membrane in every effectively. As soon as we now have obtained excessive confluency – which simulates the BBB – we administer the drug candidates.”

“We use a VIAFLO 384 – with a 96 channel head and 125 µl Sterile Filter GripTips – to each ship the medication to the apical facet and take samples from the basolateral facet of the Transwells. This enables us to examine the quantity of every drug that was in a position to permeate the barrier. This method could be troublesome to carry out with a normal multichannel pipette, as we are sometimes screening giant libraries. In distinction, it’s a easy job for the VIAFLO 384, since you’ll be able to simply program the system to aspirate from any a part of the effectively.”

“I like working with the VIAFLO 384. The system is simple to arrange and optimize and, as well as, it is vitally versatile. For instance, you do not want to load the entire deck, however can use only a single column or row, which implies that we are able to use the system to arrange and research dose responses,”

Vasco

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INTEGRA Biosciences (https://www.integra-biosciences.com) is a number one supplier of high-quality laboratory instruments and consumables for liquid dealing with and media preparation. The corporate is dedicated to creating modern options which fulfil the wants of its prospects in analysis, diagnostics and high quality management throughout the life sciences markets and medical sector. Right this moment, INTEGRA modern laboratory merchandise are extensively used all all over the world.

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