Within the newest version of Medical and Sensible Psychopharmacology within the Journal of Medical Psychiatry , Dr Andrade evaluations latest research evaluating neurodevelopmental and cognitive outcomes in youngsters with gestational publicity to antidepressants (FULL TEXT HERE – FREE). It is a nice evaluation, summarizing the findings of key research from the final decade and a extra latest examine from Christensen and colleagues on mathematical expertise in Danish school-aged youngsters.
To summarize, the Christensen examine noticed that youngsters (9 to fifteen years of age) with a historical past of prenatal publicity to antidepressants carried out worse on standardized language and arithmetic checks. Nevertheless, in a totally adjusted evaluation, publicity was not related to efficiency on language checks and was related to a really small (2 factors out of 100) however statistically considerably worse efficiency on arithmetic checks. This discovering was nonetheless noticed however attenuated in a sibling pair evaluation the place they in contrast uncovered and unexposed siblings.
Importantly, Dr. Andrade discusses a few of the challenges in decoding the info from research long-term neurodevelopmental outcomes in youngsters with prenatal publicity to antidepressants. Whereas some research have demonstrated associations between publicity to antidepressants and cognitive outcomes, he factors out that we can not exclude the affect of maternal melancholy and behaviors related to maternal melancholy. The magnitude and severity of depressive signs and comorbid psychiatric sickness are inadequately measured, and these unmeasured variables might affect outcomes and should lead to residual confounding.
Ruta Nonacs, MD PhD
Andrade C. Gestational Publicity to Antidepressant Medicine and Neurodevelopment: An Examination of Language, Arithmetic, Intelligence, and Different Cognitive Outcomes. J Clin Psychiatry. 2022 Jan 25;83(1):22f14388.
Christensen J, Trabjerg BB, Solar Y, et al. Affiliation of maternal antidepressant prescription throughout being pregnant with standardized check scores of Danish school-aged youngsters. JAMA. 2021;326(17):1725–1735.
Nonacs RM, Cohen LS. Challenges in Figuring out Outcomes of Prenatal Publicity to Antidepressants. J Clin Psychiatry. 2020 Might 12;81(3):20com13269. Free article.