Side Effects Of Hyaluronic Acid

What Are The Side Effects Of Hyaluronic Acid Injections?

Skin Care

Recently, there are stories about the side effects of hyaluronic acid everywhere. This is because hyaluronic acid is one of the most highly regarded products for skin regeneration. Hyaluronic acid provides a three-dimensional effect to areas where certain tissues are very thin. The use of hyaluronic acid in personal beauty and hygiene care is increasing.

People undergoing hyaluronic acid procedures should be aware of specific guidelines to avoid side effects and achieve optimal results. Read on to get some recommendations on what to avoid.

Side Effects Of Hyaluronic Acid

Side Effects Of Hyaluronic Acid Injections

After using hyaluronic acid, a series of measures should be followed to avoid side effects. Side effects are not always a direct result of the product, but they can arise from not following the expert’s instructions.

redness in the area

Erythema, a side effect of hyaluronic acid, is caused by trauma, such as a local injection. However, it may vary depending on the characteristics of the product used. These symptoms appear as temporary redness with slight inflammation.

This usually lasts from a few hours to up to two days, but you can speed up the healing process and use special creams after the procedure to stimulate healing.

What Are The Side Effects Of Hyaluronic Acid?

The side effects of hyaluronic acid may appear immediately or in the short term.

Bruising from hyaluronic acid

Bruising is usually expected with some inflammation and should not last longer than a few days. To minimize these side effects, apply sufficient pressure before and during the procedure and apply ice packs.

If you are taking any unnecessary anticoagulants or products, stop using them. According to a study published in <The Journal of Clinical and Aesthetic Dermatology>, the incidence of bruising after dermal fillers is 19-24%.


The amount of hyaluronic acid can lead to asymmetry. There may be a temporary difference in the volume of the face on both sides of the nose. As if one is bigger than the other.

Allergic reactions and hypersensitivity

Since hyaluronic acid is a biocompatible product, allergic reactions or hypersensitivity are rare. The body absorbs hyaluronic acid without recognizing it as an external substance. This is because its ingredients are similar to natural body substances. All allergic reactions manifest as local irritation.

skin necrosis

Skin necrosis due to pressure or blockage of blood vessels is a rare complication. The area with the greatest risk of developing these side effects is the forehead. This is because this area is irrigated by the trochlear artery without strong collateral circulation. Therefore, it does not receive blood from other sources.

<Plastic and Reconstructive Surgery> recommends that the needle be continuously moved back and forth before injecting the filler and aspiration. This can prevent skin necrosis complications.

Short-term side effects of hyaluronic acid

Some side effects of hyaluronic acids, such as the types mentioned above, are short-term, but not immediate. In other words, it appears a few days after the filler.

palpable or visible nodules

It is a common complication of nodules or as a result of the use of dermal fillers. It is classified as an inflammatory or non-inflammatory nodule. Late nodules lasting 4 weeks to 1 year or longer are often an inflammatory immune response to hyaluronic acid.

According to the American Journal of Clinical Dermatology, inflammatory nodules are more common in permanent fillings. However, there are reports of cases occurring after the use of temporary fillings.

Activates herpes simplex virus

Your professional should treat herpes as a preventive measure when injecting fillers into the lip area of a person with herpes. This is because hyaluronic acid has the side effect of activating a herpes infection that normally settles on the nerves of the face.

Long-term side effects of hyaluronic acid

Long-term complications can occur months to years after the use of hyaluronic acid. However, it is usually misdiagnosed due to the time of intervention. Therefore, it is not easy to use it in connection with these treatments.


A granulomatous foreign body reaction may occur several years after the injection of hyaluronic acid. The process is asymptomatic or accompanied by erythema and swelling.

Persistent foreign body reactions can be treated with intralesional corticosteroid injection. However, research by the American Academy of Dermatological Surgeons suggests hyaluronidase as a possible treatment for these unwanted effects.

What Are The Side Effects Of Hyaluronic Acid?

To reduce the possibility of side effects, hyaluronic acid injections should be performed by a professional.

movement of the filler

The migration of hyaluronic acid is one of the possible complications associated with soft tissue filler injection. Therefore, it should be taken into account that the applied material may not only migrate away from the injection site, but may remain in the tissue even after several years when evaluating facial nodules, lumps, and oedema.

Importance of expert treatment

There are many strategies to reduce the risk of complications from hyaluronic acid fillers. Adequate practical knowledge of experts on side effects is essential.

When the correct injection method is carried out, undesired reactions rarely occur. However, you should be aware that unexpected side effects may occur. So, get information before and after the procedure and follow the instructions.

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