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Take part in a New Analysis Research Investigating a Novel Therapy for Menopausal Despair


It’s World Menopause Day.  October 18th was designated by the Worldwide Menopause Society (IMS) to lift consciousness of the menopause and to help choices to enhance well being and well-being for girls in mid-life and past.

Some essential information to know in regards to the menopausal transition:

A Novel Therapy of Perimenopausal Despair

The transition to menopause, or perimenopause, represents the passage from reproductive to non-reproductive life. Through the perimenopause, ladies expertise irregular menstrual cycles, which replicate the big fluctuations in ovarian hormone secretion throughout this time. As well as, ladies could expertise vasomotor signs, altered sleep patterns, adjustments in cognition, and despair.  Whereas hormone substitute remedy (HRT) has been used to handle bodily signs related to the menopausal despair, a lot much less consideration has been targeted on the therapy of menopausal despair.  Considerations relating to the long-term use of HRT have restricted its use, and girls experiencing despair on this setting sometimes use conventional antidepressants, mostly serotonergic reuptake inhibitors.  Whereas these antidepressants do work for a lot of ladies, there’s a clear must develop different interventions for girls who can’t take or don’t reply to  serotonergic antidepressants.

Over the previous couple of years now we have heard an incredible deal about neurosteroids, also referred to as neuroactive steroids.  This class of compounds are steroid hormones produced within the mind and endocrine tissues which may modulate neurotransmission.  Animal research have demonstrated that neurosteroids have a broad vary of actions, together with antidepressant, anxiolytic, sedative, analgesic, anticonvulsant, neuroprotective, and neuroproliferative results.  

Whereas now we have identified in regards to the neuroactive results of steroids because the Nineteen Forties, it has been troublesome to copy the helpful results of naturally produced neurosteroids with related compounds synthesized within the laboratory.  There has just lately been some progress, and a number of other completely different neurosteroids have been examined as anticonvulsants and anesthetic brokers; nevertheless, now we have seen essentially the most  strong scientific findings with a number of completely different derivatives of allopregnanolone used as antidepressants.   Certainly one of these allopregnanolone analogues, brexanolone, was accepted by the FDA for the therapy of extreme postpartum despair and is now being marketed as Zulresso (Sage Therapeutics).  One other allopregnanolone spinoff, zuranolone, has additionally been proven to be efficient for postpartum despair.  

Given the efficacy of those neurosteroid brokers for the therapy of postpartum despair, many have speculated that derivatives of allopregnanolone could also be efficient for the therapy of different reproductive hormone-associated temper issues, together with premenstrual dysphoric dysfunction (PMDD) and menopausal despair.  Allopregnanolone is produced by the human physique as a byproduct of progesterone.  Whereas most earlier analysis has targeted on the mood-modulating results of estrogen and have speculated that falling ranges of estrogen set off depressive signs in some ladies, different research have instructed that shifting ranges of allopregnanolone could play a task within the pathophysiology of reproductive hormone-associated temper issues, together with premenstrual dysphoric dysfunction (PMDD) and menopausal despair.  In gentle of the optimistic outcomes of brexanolone for postpartum despair, there was appreciable curiosity in exploring the effectiveness of comparable neurosteroids in ladies with different kinds of reproductive hormone-associated temper issues.  

In a brand new examine, Dr. Marlene Freeman and colleagues on the Heart for Ladies’s Psychological Well being is at the moment investigating the effectiveness of pregnenolone, one other neurosteroid which is a spinoff of progesterone, for the therapy of despair in the course of the menopausal transition.  Pregnenolone is produced within the physique and is concerned within the synthesis and metabolism of different steroid hormones, together with progestogens and estrogens.  Pregnenolone is biologically lively and modulates numerous neurotransmitter techniques, together with the endocannabinoid system. Its metabolite pregnenolone sulfate is much like brexanolone and acts as a unfavorable allosteric modulator of the GABA-A receptor and can also be a optimistic allosteric modulator of the NMDA receptor.

Each preclinical and human knowledge recommend that pregnenolone could also be a promising therapy for despair. Dr. Freeman’s examine will take a look at the effectiveness of pregnenolone in ladies with menopausal despair.  

Be taught Extra Concerning the Research

For data, you may contact Ella at erossa@mgh.harvard.edu.  You may learn extra about this examine HERE.

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